InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: L3MBTL3

Summary

InnateDB Protein

IDBP-96414.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

L3MBTL3

Protein Name

l(3)mbt-like 3 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000357121

InnateDB Gene

IDBG-96410 (L3MBTL3)

Protein Structure

UniProt Annotation

Function

Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Required for normal maturation of myeloid progenitor cells (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0016568	chromatin modification

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR001660 Sterile alpha motif domain
IPR004092 Mbt repeat
IPR011510 Sterile alpha motif, type 2
IPR013761 Sterile alpha motif/pointed domain
IPR021129 Sterile alpha motif, type 1

PFAM

PF02820
PF07647
PF00536

PRINTS

PIRSF

SMART

SM00454
SM00561

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q96JM7