Version 5.4
Homo sapiens Protein: SNIP1
Summary
InnateDB Protein IDBP-96437.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SNIP1
Protein Name Smad nuclear interacting protein 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000296215
InnateDB Gene IDBG-96435 (SNIP1)
Protein Structure
UniProt Annotation
Function Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. {ECO:0000269PubMed:11567019, ECO:0000269PubMed:15378006, ECO:0000269PubMed:18632581, ECO:0000269PubMed:18794151}.
Subcellular Localization Nucleus {ECO:0000269PubMed:10887155}.
Disease Associations Psychomotor retardation, epilepsy, and craniofacial dysmorphism (PMRED) [MIM:614501]: A disease characterized by severe psychomotor retardation, intractable seizures, dysmorphic features, and a lumpy skull surface. Patients are hypotonic and have poor feeding in the neonatal period. {ECO:0000269PubMed:22279524}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Ubiquitous, with highest expression in heart and skeletal muscle. {ECO:0000269PubMed:10887155}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 67 [view]
Protein-Protein 65 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0035196 production of miRNAs involved in gene silencing by miRNA
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR000253 Forkhead-associated (FHA) domain
IPR008984 SMAD/FHA domain
PFAM PF00498
PRINTS
PIRSF
SMART SM00240
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TAD8
PhosphoSite PhosphoSite-Q8TAD8
TrEMBL B1AK66
UniProt Splice Variant
Entrez Gene 79753
UniGene Hs.613500
RefSeq NP_078976
HUGO HGNC:30587
OMIM 608241
CCDS CCDS419
HPRD 06999
IMGT
EMBL AK022615 AK027622 AK315574 AY081909 BC027040 CH471059
GenPept AAH27040 AAL91140 BAB14134 BAB55241 BAG37948 EAX07338

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca