InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GNL2

Summary

InnateDB Protein

IDBP-96459.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GNL2

Protein Name

guanine nucleotide binding protein-like 2 (nucleolar)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000362153

InnateDB Gene

IDBG-96457 (GNL2)

Protein Structure

UniProt Annotation

Function

GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. {ECO:0000250}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000269PubMed:12429849}.

Disease Associations

Tissue Specificity

Ubiquitously expressed at relatively low levels in all human tissues tested, with the highest level of expression in the testes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005525	GTP binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006184	GTP catabolic process
GO:0008150	biological_process
GO:0042254	ribosome biogenesis

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR006073 GTP binding domain
IPR012971 Nucleolar GTP-binding protein 2, N-terminal domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01926
PF08153

PRINTS

PR00326

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q13823