InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDCA8

Summary

InnateDB Protein

IDBP-96470.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDCA8

Protein Name

cell division cycle associated 8

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000362146

InnateDB Gene

IDBG-96468 (CDCA8)

Protein Structure

UniProt Annotation

Function

Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment. {ECO:0000269PubMed:15249581, ECO:0000269PubMed:15260989, ECO:0000269PubMed:16571674, ECO:0000269PubMed:18243099}.

Subcellular Localization

Nucleus, nucleolus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with SENP3 in the nucleolus in interphase cells.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.

Experimentally validated
Total	39 [view]
Protein-Protein	37 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000089	mitotic metaphase
GO:0000278	mitotic cell cycle
GO:0007067	mitotic nuclear division
GO:0051276	chromosome organization

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005819	spindle
GO:0005829	cytosol
GO:0010369	chromocenter
GO:0030496	midbody
GO:0032133	chromosome passenger complex
GO:0043234	protein complex
GO:0045171	intercellular bridge