Version 5.4
Homo sapiens Protein: GPR78
Summary
InnateDB Protein IDBP-9654.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPR78
Protein Name G protein-coupled receptor 78
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000371927
InnateDB Gene IDBG-9650 (GPR78)
Protein Structure
UniProt Annotation
Function Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. {ECO:0000269PubMed:17363172}.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity High level of expression in placenta. Expressed throughout the brain at low level. No expression detected in skeletal muscle, lung, heart, liver, pancreas, or kidney. {ECO:0000269PubMed:17363172}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
PFAM PF00001
PRINTS PR00237
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96P69
PhosphoSite PhosphoSite-Q96P69
TrEMBL D6RB95
UniProt Splice Variant
Entrez Gene 27201
UniGene Hs.740355
RefSeq NP_543009
HUGO HGNC:4528
OMIM 606921
CCDS CCDS3403
HPRD 06081
IMGT
EMBL AB065673 AC105345 AF411107 AK128807 AK313038 AY359107 BC057778 BC069343 BC069813 CH471131 JF810885
GenPept AAH57778 AAH69343 AAH69813 AAL26479 AAQ89465 AEP43752 BAC05898 BAG35871 BAG54739 EAW82336

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca