InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MED23

Summary

InnateDB Protein

IDBP-96541.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MED23

Protein Name

mediator complex subunit 23

Synonyms

ARC130; CRSP130; CRSP133; CRSP3; DRIP130; MRT18; SUR-2; SUR2;

Species

Homo sapiens

Ensembl Protein

ENSP00000357047

InnateDB Gene

IDBG-96537 (MED23)

Protein Structure

UniProt Annotation

Function

Required for transcriptional activation subsequent to the assembly of the preinitiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling. {ECO:0000250, ECO:0000269PubMed:10353252, ECO:0000269PubMed:14759369, ECO:0000269PubMed:16595664}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Mental retardation, autosomal recessive 18 (MRT18) [MIM:614249]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269PubMed:21868677}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	67 [view]
Protein-Protein	64 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0005515	protein binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0010467	gene expression