Version 5.4
Homo sapiens Protein: RHBDL2
Summary
InnateDB Protein IDBP-96586.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RHBDL2
Protein Name rhomboid, veinlet-like 2 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000362081
InnateDB Gene IDBG-96584 (RHBDL2)
Protein Structure
UniProt Annotation
Function Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Known substrate: EFNB3. {ECO:0000269PubMed:11672525, ECO:0000269PubMed:15047175}.
Subcellular Localization Rhomboid-related protein 2, C-terminal fragment: Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR017213 Peptidase S54, rhomboid, metazoan
IPR022764 Peptidase S54, rhomboid domain
PFAM PF01694
PRINTS
PIRSF PIRSF037470
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NX52
PhosphoSite PhosphoSite-Q9NX52
TrEMBL B7Z1Y9
UniProt Splice Variant
Entrez Gene 54933
UniGene Hs.633604
RefSeq NP_060291
HUGO HGNC:16083
OMIM 608962
CCDS CCDS30680
HPRD 07151
IMGT
EMBL AK000442 AK097621 AK294115 AL139260 AL714019 AY126343 BC013103 BC137108 BC137110
GenPept AAH13103 AAI37109 AAI37111 AAM95697 BAA91168 BAG53496 BAH11675 CAI23052

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca