InnateDB Protein
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IDBP-96588.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RHBDL2
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Protein Name
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rhomboid, veinlet-like 2 (Drosophila)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000289248
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InnateDB Gene
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IDBG-96584 (RHBDL2)
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Protein Structure
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Function |
Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Known substrate: EFNB3. {ECO:0000269PubMed:11672525, ECO:0000269PubMed:15047175}.
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Subcellular Localization |
Rhomboid-related protein 2, C-terminal fragment: Cell membrane; Multi-pass membrane protein.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0004252
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serine-type endopeptidase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR017213
Peptidase S54, rhomboid, metazoan
IPR022764
Peptidase S54, rhomboid domain
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PFAM |
PF01694
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PRINTS |
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PIRSF |
PIRSF037470
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NX52
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PhosphoSite |
PhosphoSite-Q9NX52
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TrEMBL |
B7Z1Y9
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UniProt Splice Variant |
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Entrez Gene |
54933
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UniGene |
Hs.633604
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RefSeq |
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HUGO |
HGNC:16083
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OMIM |
608962
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CCDS |
CCDS30680
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HPRD |
07151
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IMGT |
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EMBL |
AK000442
AK097621
AK294115
AL139260
AL714019
AY126343
BC013103
BC137108
BC137110
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GenPept |
AAH13103
AAI37109
AAI37111
AAM95697
BAA91168
BAG53496
BAH11675
CAI23052
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