InnateDB Protein
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IDBP-96607.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NDUFS5
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Protein Name
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NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase)
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Synonyms
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CI-15k; CI15K;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000362060
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InnateDB Gene
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IDBG-96605 (NDUFS5)
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Protein Structure
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Function |
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
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Subcellular Localization |
Mitochondrion. Mitochondrion inner membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Mitochondrion intermembrane space {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0008137
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NADH dehydrogenase (ubiquinone) activity
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Biological Process |
GO:0006120
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mitochondrial electron transport, NADH to ubiquinone
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GO:0022904
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respiratory electron transport chain
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GO:0032981
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mitochondrial respiratory chain complex I assembly
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GO:0044237
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cellular metabolic process
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GO:0044281
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small molecule metabolic process
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Cellular Component |
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PDB ID |
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InterPro |
IPR013892
Cytochrome c oxidase biogenesis protein Cmc1-like
IPR019342
NADH:ubiquinone oxidoreductase, iron-sulphur subunit 5
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PFAM |
PF08583
PF10200
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O43920
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PhosphoSite |
PhosphoSite-O43920
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TrEMBL |
Q6IBA0
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UniProt Splice Variant |
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Entrez Gene |
4725
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UniGene |
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RefSeq |
NP_004543
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HUGO |
HGNC:7712
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OMIM |
603847
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CCDS |
CCDS434
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HPRD |
11961
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IMGT |
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EMBL |
AF020352
AF047434
AK312188
BC001884
BC093057
CH471059
CR456904
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GenPept |
AAB87866
AAC39878
AAH01884
AAH93057
BAG35121
CAG33185
EAX07286
EAX07287
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