InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STX7

Summary

InnateDB Protein

IDBP-96641.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STX7

Protein Name

syntaxin 7

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000356918

InnateDB Gene

IDBG-96639 (STX7)

Protein Structure

UniProt Annotation

Function

May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes.

Subcellular Localization

Early endosome membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Highest expression is found in placenta followed by heart, skeletal muscle, kidney and brain. Low expression is found in pancreas, lung and liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	44 [view]
Protein-Protein	44 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000149	SNARE binding
GO:0005484	SNAP receptor activity
GO:0005515	protein binding

Biological Process

GO:0006886	intracellular protein transport
GO:0006892	post-Golgi vesicle-mediated transport
GO:0016079	synaptic vesicle exocytosis
GO:0016192	vesicle-mediated transport

Cellular Component

GO:0005765	lysosomal membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031201	SNARE complex
GO:0031901	early endosome membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome