Version 5.4
| Homo sapiens Protein: TAAR5 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-96659.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | TAAR5 | ||||||||
| Protein Name | trace amine associated receptor 5 | ||||||||
| Synonyms | PNR; | ||||||||
| Species | Homo sapiens | ||||||||
| Ensembl Protein | ENSP00000258034 | ||||||||
| InnateDB Gene | IDBG-96657 (TAAR5) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Olfactory receptor specific for trimethylamine, a trace amine. Also activated at lower level by dimethylethylamine. Trimethylamine is a bacterial metabolite found in some animal odors, and to humans it is a repulsive odor associated with bad breath and spoiled food. This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase. {ECO:0000269PubMed:23393561}. | ||||||||
| Subcellular Localization | Cell membrane {ECO:0000269PubMed:23393561}; Multi-pass membrane protein {ECO:0000269PubMed:23393561}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Expressed almost exclusively in skeletal muscle and selected areas of the brain, such amygdala, hippocampus, caudate nucleus, thalamus and hypothalamus. Weak expression is also find in substantia nigra. {ECO:0000269PubMed:9464258}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | |||||||||
| InterPro |
IPR000276
G protein-coupled receptor, rhodopsin-like IPR009132 Trace amine associated receptor family IPR017452 GPCR, rhodopsin-like, 7TM |
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| PFAM |
PF00001
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| PRINTS |
PR00237
PR01830 |
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| PIRSF | |||||||||
| SMART | |||||||||
| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | O14804 | ||||||||
| PhosphoSite | PhosphoSite- | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 9038 | ||||||||
| UniGene | Hs.248198 | ||||||||
| RefSeq | NP_003958 | ||||||||
| HUGO | HGNC:30236 | ||||||||
| OMIM | 607405 | ||||||||
| CCDS | CCDS5156 | ||||||||
| HPRD | 08459 | ||||||||
| IMGT | |||||||||
| EMBL | AF021818 AL513524 AY702306 BC069171 BC095541 BC112209 BC112211 CH471051 FJ372547 | ||||||||
| GenPept | AAC39581 AAH69171 AAH95541 AAI12210 AAI12212 AAV70123 ACP18682 CAH72100 EAW48025 | ||||||||