InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BMP8B

Summary

InnateDB Protein

IDBP-96766.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BMP8B

Protein Name

bone morphogenetic protein 8b

Synonyms

BMP8; OP2;

Species

Homo sapiens

Ensembl Protein

ENSP00000361915

InnateDB Gene

IDBG-96764 (BMP8B)

Protein Structure

UniProt Annotation

Function

Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0008083	growth factor activity

Biological Process

GO:0001501	skeletal system development
GO:0001503	ossification
GO:0030154	cell differentiation
GO:0040007	growth
GO:0051216	cartilage development

Cellular Component

GO:0005615

extracellular space

Protein Structure and Domains

PDB ID

InterPro

IPR001111 Transforming growth factor-beta, N-terminal
IPR001839 Transforming growth factor-beta, C-terminal
IPR002405 Inhibin, alpha subunit
IPR029034 Cystine-knot cytokine

PFAM

PF00688
PF00019

PRINTS

PR00669

PIRSF

SMART

SM00204

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt