Version 5.4
Homo sapiens Protein: SLC2A12
Summary
InnateDB Protein IDBP-96769.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC2A12
Protein Name solute carrier family 2 (facilitated glucose transporter), member 12
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000275230
InnateDB Gene IDBG-96767 (SLC2A12)
Protein Structure
UniProt Annotation
Function Facilitative glucose transporter. {ECO:0000250}.
Subcellular Localization Endomembrane system {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000269PubMed:11832379}. Note=Localizes primarily perinuclear region in the absence of insulin.
Disease Associations
Tissue Specificity Predominantly expressed in skeletal muscle, heart and prostate, with lower levels in brain, placenta and kidney. {ECO:0000269PubMed:11832379}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0022857 transmembrane transporter activity
GO:0022891 substrate-specific transmembrane transporter activity
Biological Process
GO:0015758 glucose transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR003663 Sugar/inositol transporter
IPR005828 General substrate transporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain
PFAM PF00083
PF07690
PRINTS PR00171
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TD20
PhosphoSite PhosphoSite-Q8TD20
TrEMBL
UniProt Splice Variant
Entrez Gene 154091
UniGene Hs.635693
RefSeq NP_660159
HUGO HGNC:18067
OMIM 610372
CCDS CCDS5169
HPRD 11572
IMGT
EMBL AK056554 AK122628 AL035699 AL449363 AY046419 BC070149 CH471051
GenPept AAH70149 AAL02327 BAB71214 BAG53629 CAD92514 CAI17977 EAW47994

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca