InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRIT1

Summary

InnateDB Protein

IDBP-96796.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIT1

Protein Name

tRNA isopentenyltransferase 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000361905

InnateDB Gene

IDBG-96784 (TRIT1)

Protein Structure

UniProt Annotation

Function

Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A). {ECO:0000269PubMed:11111046}.

Subcellular Localization

Isoform 1: Mitochondrion {ECO:0000305}.Isoform 4: Mitochondrion {ECO:0000305}.Isoform 2: Cytoplasm {ECO:0000305}.Isoform 3: Cytoplasm {ECO:0000305}.Isoform 5: Cytoplasm {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0004161	dimethylallyltranstransferase activity
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0016740	transferase activity
GO:0046872	metal ion binding
GO:0052381	tRNA dimethylallyltransferase activity

Biological Process

GO:0008033	tRNA processing
GO:0009058	biosynthetic process

Cellular Component

GO:0005575	cellular_component
GO:0005739	mitochondrion

Protein Structure and Domains

PDB ID

InterPro

IPR002627 tRNA isopentenyltransferase
IPR002648 Isopentenyl transferase
IPR003604 Zinc finger, U1-type
IPR018022 tRNA delta(2)-isopentenylpyrophosphate transferase
IPR022755 Zinc finger, double-stranded RNA binding
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01715
PF01745
PF12171

PRINTS

PIRSF

PIRSF000507

SMART

SM00451

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt