Version 5.4
| Homo sapiens Protein: CPZ | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-9687.7 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | CPZ | ||||||||
| Protein Name | carboxypeptidase Z | ||||||||
| Synonyms | |||||||||
| Species | Homo sapiens | ||||||||
| Ensembl Protein | ENSP00000315074 | ||||||||
| InnateDB Gene | IDBG-9683 (CPZ) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing. {ECO:0000269PubMed:11766880, ECO:0000269PubMed:12417617, ECO:0000269PubMed:9099699}. | ||||||||
| Subcellular Localization | Secreted, extracellular space, extracellular matrix {ECO:0000269PubMed:10671522}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | In placenta, it is present within invasive trophoblasts and in the surrounding extracellular space. Also present in amnion cells, but is not readily apparent in the extracellular matrix of this cell type. Present in normal pituitary gland and neoplastic pituitary gland (especially POMC-, GH- and PRL-producing adenomas) (at protein level). Widely expressed. {ECO:0000269PubMed:10671522, ECO:0000269PubMed:12417617, ECO:0000269PubMed:9099699}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | |||||||||
| InterPro |
IPR000834
Peptidase M14, carboxypeptidase A IPR008969 Carboxypeptidase-like, regulatory domain IPR020067 Frizzled domain |
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| PFAM |
PF00246
PF01392 |
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| PRINTS |
PR00765
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| PIRSF | |||||||||
| SMART |
SM00631
SM00063 |
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q66K79 | ||||||||
| PhosphoSite | PhosphoSite- | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 8532 | ||||||||
| UniGene | Hs.61995 | ||||||||
| RefSeq | NP_003643 | ||||||||
| HUGO | HGNC:2333 | ||||||||
| OMIM | 603105 | ||||||||
| CCDS | CCDS3404 | ||||||||
| HPRD | 04376 | ||||||||
| IMGT | |||||||||
| EMBL | AC105345 AK056317 BC006393 BC080539 U83411 | ||||||||
| GenPept | AAB58911 AAH80539 BAB71147 | ||||||||