InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DEM1

Summary

InnateDB Protein

IDBP-96953.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DEM1

Protein Name

defects in morphology 1 homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000351328

InnateDB Gene

IDBG-96951 (DEM1)

Protein Structure

UniProt Annotation

Function

Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'-directionality activity. {ECO:0000269PubMed:23095756}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:23095756}. Cytoplasm, cytosol {ECO:0000269PubMed:23095756}. Note=Localizes to repair foci in response to DNA damage.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0008310	single-stranded DNA 3'-5' exodeoxyribonuclease activity
GO:0042803	protein homodimerization activity
GO:0045145	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GO:0046872	metal ion binding
GO:0051539	4 iron, 4 sulfur cluster binding