Version 5.4
Homo sapiens Protein: IL22RA2
Summary
InnateDB Protein IDBP-96996.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL22RA2
Protein Name interleukin 22 receptor, alpha 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000296979
InnateDB Gene IDBG-96992 (IL22RA2)
Protein Structure
UniProt Annotation
Function Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.Isoform 1 may play a role in establishing and maintaining successful pregnancy.
Subcellular Localization Secreted {ECO:0000269PubMed:12700595}.
Disease Associations
Tissue Specificity Expressed in placenta, spleen, breast, skin and lung. Also detected in intestinal tract, testis, brain, heart and thymus. No expression found in prostate, bladder, kidney, ovary, muscle, bone marrow, liver and uterus. Isoform 1 is expressed only in placenta. Isoform 2 is expressed in placenta and breast and at lower level in spleen, skin, thymus and stomach. {ECO:0000269PubMed:11481447, ECO:0000269PubMed:11607789, ECO:0000269PubMed:15201862}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042017 interleukin-22 binding
GO:0042018 interleukin-22 receptor activity
Biological Process
GO:0019221 cytokine-mediated signaling pathway
GO:0042516 regulation of tyrosine phosphorylation of Stat3 protein
Cellular Component
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR003961 Fibronectin, type III
IPR015373 Interferon alpha/beta receptor, beta chain
PFAM PF00041
PF01108
PF09294
PRINTS
PIRSF
SMART SM00060
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q969J5
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 116379
UniGene Hs.126891
RefSeq NP_851826
HUGO HGNC:14901
OMIM 606648
CCDS CCDS5183
HPRD 05973
IMGT
EMBL AJ297262 AJ313161 AJ313162 AL050337 AY040566 AY040567 AY040568 AY044429 AY358111 AY358737 AY779023 BC125167 BC125168 CH471051
GenPept AAI25168 AAI25169 AAK85714 AAK85715 AAK85716 AAK91775 AAQ88478 AAQ89097 AAV31775 CAC83097 CAC85634 CAC85635 CAI21589 CAI21590 CAI21591 EAW47933

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca