Version 5.4
Homo sapiens Protein: CITED4
Summary
InnateDB Protein IDBP-97070.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CITED4
Protein Name Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000361721
InnateDB Gene IDBG-97068 (CITED4)
Protein Structure
UniProt Annotation
Function Acts as transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells. {ECO:0000269PubMed:11744733, ECO:0000269PubMed:15342390}.
Subcellular Localization Nucleus {ECO:0000269PubMed:11744733, ECO:0000269PubMed:15342390}. Cytoplasm {ECO:0000269PubMed:11744733, ECO:0000269PubMed:15342390}.
Disease Associations
Tissue Specificity Expressed in most tissues examined with highest levels of expression in heart, liver, skeletal muscle and pancreas. Also expressed in bladder cell line ECV-304 and in various breast cancer cell lines. Also detected in both in situ and invasive breast tumors where its expression is down-regulated and mostly restricted to the cytoplasm of malignant epithelium. Down-regulation of expression is associated with elevated levels of HIF1A and increased tumor growth and angiogenesis. {ECO:0000269PubMed:11744733, ECO:0000269PubMed:15342390}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0043627 response to estrogen
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR007576 CITED
PFAM PF04487
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96RK1
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 163732
UniGene
RefSeq NP_597724
HUGO HGNC:18696
OMIM 606815
CCDS CCDS458
HPRD 06011
IMGT
EMBL AF362074 AF466291 BC035496 BC052559
GenPept AAH35496 AAH52559 AAK64235 AAL73989

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca