InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CECR2

Summary

InnateDB Protein

IDBP-972.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CECR2

Protein Name

cat eye syndrome chromosome region, candidate 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000262608

InnateDB Gene

IDBG-970 (CECR2)

Protein Structure

UniProt Annotation

Function

Part of the CERF (CECR2-containing-remodeling factor) complex, which facilitates the perturbation of chromatin structure in an ATP-dependent manner. May be involved through its interaction with LRPPRC in the integration of cytoskeletal network with vesicular trafficking, nucleocytosolic shuttling, transcription, chromosome remodeling and cytokinesis. {ECO:0000269PubMed:15640247}.

Subcellular Localization

Disease Associations

Tissue Specificity

Highly expressed in skeletal muscle, thymus, placenta and lung. Expressed at lower level in brain, heart, colon, spleen, kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000910	cytokinesis
GO:0006309	apoptotic DNA fragmentation
GO:0007010	cytoskeleton organization
GO:0016192	vesicle-mediated transport
GO:0043044	ATP-dependent chromatin remodeling
GO:0097194	execution phase of apoptosis