InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPCS

Summary

InnateDB Protein

IDBP-97209.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPCS

Protein Name

phosphopantothenoylcysteine synthetase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000361642

InnateDB Gene

IDBG-97205 (PPCS)

Protein Structure

UniProt Annotation

Function

Catalyzes the first step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'- phosphopantothenate to form 4-phosphopantothenoylcysteine. {ECO:0000269PubMed:11923312, ECO:0000269PubMed:12906824}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	2 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004632	phosphopantothenate--cysteine ligase activity

Biological Process

GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0009108	coenzyme biosynthetic process
GO:0015937	coenzyme A biosynthetic process
GO:0015939	pantothenate metabolic process
GO:0044281	small molecule metabolic process