Version 5.4
Homo sapiens Protein: ELOVL1
Summary
InnateDB Protein IDBP-97424.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ELOVL1
Protein Name ELOVL fatty acid elongase 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000361536
InnateDB Gene IDBG-97422 (ELOVL1)
Protein Structure
UniProt Annotation
Function Condensing enzyme that catalyzes the synthesis of both saturated and monounsaturated very long chain fatty acids (VLCFAs). Exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs. {ECO:0000269PubMed:20166112, ECO:0000269PubMed:20937905}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:20937905}; Multi-pass membrane protein {ECO:0000269PubMed:20937905}.
Disease Associations
Tissue Specificity Ubiquitous. {ECO:0000269PubMed:20937905}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 9 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0009922 fatty acid elongase activity
Biological Process
GO:0019367 fatty acid elongation, saturated fatty acid
GO:0019432 triglyceride biosynthetic process
GO:0030148 sphingolipid biosynthetic process
GO:0034625 fatty acid elongation, monounsaturated fatty acid
GO:0035338 long-chain fatty-acyl-CoA biosynthetic process
GO:0042761 very long-chain fatty acid biosynthetic process
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030176 integral component of endoplasmic reticulum membrane
Protein Structure and Domains
PDB ID
InterPro IPR002076 GNS1/SUR4 membrane protein
PFAM PF01151
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BW60
PhosphoSite PhosphoSite-Q9BW60
TrEMBL
UniProt Splice Variant
Entrez Gene 64834
UniGene Hs.25597
RefSeq NP_073732
HUGO HGNC:14418
OMIM 611813
CCDS CCDS485
HPRD 10935
IMGT
EMBL AF151846 AF336793 AK001653 AK222498 AK298163 AL139289 BC000618
GenPept AAD34083 AAH00618 AAL71993 BAA91813 BAD96218 BAG60436 CAB92758

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca