InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTPRF

Summary

InnateDB Protein

IDBP-97494.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTPRF

Protein Name

protein tyrosine phosphatase, receptor type, F

Synonyms

BNAH2; LAR;

Species

Homo sapiens

Ensembl Protein

ENSP00000353030

InnateDB Gene

IDBG-97490 (PTPRF)

Protein Structure

UniProt Annotation

Function

Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity.The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	27 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0016791	phosphatase activity
GO:0032403	protein complex binding

Biological Process

GO:0006470	protein dephosphorylation
GO:0007155	cell adhesion
GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway
GO:0016311	dephosphorylation
GO:0016477	cell migration
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:1900121	negative regulation of receptor binding

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF00041
PF01108
PF07679

PRINTS

PR00700

PIRSF

SMART

SM00194
SM00404
SM00408
SM00409
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt