InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KDM4A

Summary

InnateDB Protein

IDBP-97514.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KDM4A

Protein Name

lysine (K)-specific demethylase 4A

Synonyms

JHDM3A; JMJD2; JMJD2A; TDRD14A;

Species

Homo sapiens

Ensembl Protein

ENSP00000361473

InnateDB Gene

IDBG-97512 (KDM4A)

Protein Structure

UniProt Annotation

Function

Histone demethylase that specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.Isoform 2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00537, ECO:0000269PubMed:15927959, ECO:0000269PubMed:16024779}.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:15927959}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	28 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0031625	ubiquitin protein ligase binding
GO:0035064	methylated histone binding
GO:0051864	histone demethylase activity (H3-K36 specific)

Biological Process

GO:0006351	transcription, DNA-templated
GO:0014898	cardiac muscle hypertrophy in response to stress
GO:0016032	viral process
GO:0016577	histone demethylation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0055114	oxidation-reduction process
GO:0070544	histone H3-K36 demethylation

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001965 Zinc finger, PHD-type
IPR002999 Tudor domain
IPR003347 JmjC domain
IPR003349 Transcription factor jumonji, JmjN
IPR011011 Zinc finger, FYVE/PHD-type

PFAM

PF00567
PF02373
PF08007
PF02375

PRINTS

PIRSF

SMART

SM00249
SM00333
SM00558
SM00545

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O75164