InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: B4GALT2

Summary

InnateDB Protein

IDBP-97642.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

B4GALT2

Protein Name

UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2

Synonyms

B4Gal-T2; B4Gal-T3; beta4Gal-T2;

Species

Homo sapiens

Ensembl Protein

ENSP00000349293

InnateDB Gene

IDBG-97636 (B4GALT2)

Protein Structure

UniProt Annotation

Function

Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Can produce lactose.

Subcellular Localization

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Trans cisternae of Golgi stack.

Disease Associations

Tissue Specificity

Weakly expressed in various tissues. Highest expression in prostate, testis, ovary, intestine, muscle, and in fetal brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003831	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
GO:0003945	N-acetyllactosamine synthase activity
GO:0004461	lactose synthase activity
GO:0008378	galactosyltransferase activity
GO:0046872	metal ion binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0018146	keratan sulfate biosynthetic process
GO:0018279	protein N-linked glycosylation via asparagine
GO:0030203	glycosaminoglycan metabolic process
GO:0042339	keratan sulfate metabolic process
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0044281	small molecule metabolic process