Version 5.4
Homo sapiens Protein: KLF17
Summary
InnateDB Protein IDBP-97672.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLF17
Protein Name Kruppel-like factor 17
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000361373
InnateDB Gene IDBG-97670 (KLF17)
Protein Structure
UniProt Annotation
Function Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0044212 transcription regulatory region DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007276 gamete generation
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF00096
PRINTS
PIRSF
SMART SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5JT82
PhosphoSite PhosphoSite-Q5JT82
TrEMBL
UniProt Splice Variant
Entrez Gene 128209
UniGene Hs.567674
RefSeq NP_775755
HUGO HGNC:18830
OMIM 609602
CCDS CCDS508
HPRD 08272
IMGT
EMBL AK097479 AL356653 BC049844
GenPept AAH49844 BAC05070 CAI15911

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca