InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TAB2

Summary

InnateDB Protein

IDBP-97696.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAB2

Protein Name

TGF-beta activated kinase 1/MAP3K7 binding protein 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000356426

InnateDB Gene

IDBG-97690 (TAB2)

Protein Structure

UniProt Annotation

Function

Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'- linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development. {ECO:0000269PubMed:10882101, ECO:0000269PubMed:11460167, ECO:0000269PubMed:20493459}.

Subcellular Localization

Membrane {ECO:0000269PubMed:10882101}; Peripheral membrane protein {ECO:0000269PubMed:10882101}. Cytoplasm, cytosol {ECO:0000269PubMed:10882101}. Note=Following IL1 stimulation, translocation occurs from the membrane to cytosol.

Disease Associations

Congenital heart defects, multiple types, 2 (CHTD2) [MIM:614980]: A disease characterized by congenital developmental abnormalities involving structures of the heart. CHTD2 patients have left ventricular outflow tract obstruction, subaortic stenosis, residual aortic regurgitation, atrial fibrillation, bicuspid aortic valve and aortic dilation. {ECO:0000269PubMed:20493459}. Note=The disease is caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving TAB2 has been found in a family with congenital heart disease. Translocation t(2;6)(q21;q25).

Tissue Specificity

Widely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of the conotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves. {ECO:0000269PubMed:10882101, ECO:0000269PubMed:20493459}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 131 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	131 [view]
Protein-Protein	128 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0070530	K63-linked polyubiquitin binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0002224	toll-like receptor signaling pathway
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0007249	I-kappaB kinase/NF-kappaB signaling
GO:0007254	JNK cascade
GO:0007507	heart development
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034146	toll-like receptor 5 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0034166	toll-like receptor 10 signaling pathway
GO:0035666	TRIF-dependent toll-like receptor signaling pathway
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0045860	positive regulation of protein kinase activity
GO:0050852	T cell receptor signaling pathway
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051403	stress-activated MAPK cascade
GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway