InnateDB Protein
|
IDBP-97787.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
PCMT1
|
Protein Name
|
protein-L-isoaspartate (D-aspartate) O-methyltransferase
|
Synonyms
|
PIMT;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000356350
|
InnateDB Gene
|
IDBG-97785 (PCMT1)
|
Protein Structure
|
|
Function |
Catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. Acts on microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin carboxyl- terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Cytoplasm.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
49
[view]
|
Protein-Protein |
46
[view]
|
Protein-DNA |
3
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
4 [view]
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0004719
|
protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
|
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR000682
Protein-L-isoaspartate(D-aspartate) O-methyltransferase
IPR029063
S-adenosyl-L-methionine-dependent methyltransferase-like
|
PFAM |
PF01135
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
P22061
|
PhosphoSite |
PhosphoSite-P22061
|
TrEMBL |
B7Z972
|
UniProt Splice Variant |
|
Entrez Gene |
5110
|
UniGene |
Hs.714086
|
RefSeq |
NP_001238980
|
HUGO |
HGNC:8728
|
OMIM |
176851
|
CCDS |
CCDS75534
|
HPRD |
08908
|
IMGT |
|
EMBL |
AK289724
AK304532
AL355312
BC007501
BC008748
CH471051
D13892
D25545
D25546
D25547
M93008
M93009
S73902
S73903
S73905
U49740
|
GenPept |
AAA90933
AAA90934
AAB38386
AAC60639
AAC60640
AAC60641
AAH07501
AAH08748
BAA02991
BAA05028
BAA05029
BAA05030
BAF82413
BAH14208
EAW47786
|
|
|