InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ULBP2

Summary

InnateDB Protein

IDBP-97844.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ULBP2

Protein Name

UL16 binding protein 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000356320

InnateDB Gene

IDBG-97842 (ULBP2)

Protein Structure

UniProt Annotation

Function

Ligand for the KLRK1/NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. {ECO:0000269PubMed:11777960}.

Subcellular Localization

Cell membrane; Lipid-anchor, GPI-anchor. Secreted.

Disease Associations

Tissue Specificity

Expressed in various types of cancer cell lines and in the fetus, but not in normal tissues. {ECO:0000269PubMed:11444831}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0046703	natural killer cell lectin-like receptor binding

Biological Process

GO:0006955	immune response
GO:0019882	antigen processing and presentation
GO:0030101	natural killer cell activation
GO:0042267	natural killer cell mediated cytotoxicity