InnateDB Protein
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IDBP-97927.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MTHFD1L
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Protein Name
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methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
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Synonyms
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dJ292B18.2; FTHFSDC1; MTC1THFS;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000356276
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InnateDB Gene
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IDBG-97919 (MTHFD1L)
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Protein Structure
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Function |
May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2. {ECO:0000250}.
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Subcellular Localization |
Mitochondrion {ECO:0000269PubMed:12937168}.
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Disease Associations |
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Tissue Specificity |
Detected in most tissues, highest expression found in placenta, thymus and brain. Low expression is found in liver and skeletal muscle. Up-regulated in colon adenocarcinoma. {ECO:0000269PubMed:12937168, ECO:0000269PubMed:15013446}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
14
[view]
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Protein-Protein |
14
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000672
Tetrahydrofolate dehydrogenase/cyclohydrolase
IPR020630
Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
IPR020631
Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
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PFAM |
PF00763
PF02882
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PRINTS |
PR00085
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6UB35
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PhosphoSite |
PhosphoSite-Q6UB35
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TrEMBL |
Q5JYA4
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UniProt Splice Variant |
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Entrez Gene |
25902
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UniGene |
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RefSeq |
NP_001229698
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HUGO |
HGNC:21055
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OMIM |
611427
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CCDS |
CCDS56457
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HPRD |
09967
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IMGT |
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EMBL |
AB127387
AK024798
AL035086
AL049694
AL117452
AL133260
AY374130
AY374131
BC008629
BC017477
BC110319
CH471051
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GenPept |
AAH08629
AAH17477
AAI10320
AAQ82696
AAQ82697
BAB15009
BAD93193
CAB55934
CAI42794
CAI95678
CAI95774
EAW47762
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