Version 5.4
Homo sapiens Protein: TOE1
Summary
InnateDB Protein IDBP-97930.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TOE1
Protein Name target of EGR1, member 1 (nuclear)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000361162
InnateDB Gene IDBG-97928 (TOE1)
Protein Structure
UniProt Annotation
Function Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. {ECO:0000269PubMed:12562764}.
Subcellular Localization Nucleus, nucleolus {ECO:0000269PubMed:12562764}. Nucleus speckle {ECO:0000269PubMed:12562764}. Note=Localizes to nuclear speckles.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 45 [view]
Protein-Protein 44 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0016607 nuclear speck
Protein Structure and Domains
PDB ID
InterPro IPR000571 Zinc finger, CCCH-type
IPR006941 Ribonuclease CAF1
IPR012337 Ribonuclease H-like domain
PFAM PF00642
PF04857
PRINTS
PIRSF
SMART SM00356
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96GM8
PhosphoSite PhosphoSite-Q96GM8
TrEMBL B3KSC7
UniProt Splice Variant
Entrez Gene 114034
UniGene Hs.607639
RefSeq NP_079353
HUGO HGNC:15954
OMIM 613931
CCDS CCDS521
HPRD 18212
IMGT
EMBL AK024011 AK093320 AL359540 AY169960 BC009364 CR457320
GenPept AAH09364 AAN75441 BAB14774 BAG52689 CAG33601 CAI21722

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca