InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RAD54L

Summary

InnateDB Protein

IDBP-98100.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAD54L

Protein Name

RAD54-like (S. cerevisiae)

Synonyms

hHR54; HR54; hRAD54; RAD54A;

Species

Homo sapiens

Ensembl Protein

ENSP00000361043

InnateDB Gene

IDBG-98098 (RAD54L)

Protein Structure

UniProt Annotation

Function

Involved in DNA repair and mitotic recombination. Functions in the recombinational DNA repair (RAD52) pathway. Dissociates RAD51 from nucleoprotein filaments formed on dsDNA. Could be involved in the turnover of RAD51 protein-dsDNA filaments (By similarity). May play also an essential role in telomere length maintenance and telomere capping in mammalian cells. {ECO:0000250, ECO:0000269PubMed:11459989, ECO:0000269PubMed:12205100, ECO:0000269PubMed:9774452}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:8805304}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	6 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0016817	hydrolase activity, acting on acid anhydrides
GO:0036310	annealing helicase activity

Biological Process

GO:0000724	double-strand break repair via homologous recombination
GO:0000733	DNA strand renaturation
GO:0006281	DNA repair
GO:0006302	double-strand break repair
GO:0006310	DNA recombination
GO:0006974	cellular response to DNA damage stimulus
GO:0007126	meiotic nuclear division
GO:0008152	metabolic process
GO:0010212	response to ionizing radiation
GO:0042493	response to drug
GO:0051276	chromosome organization

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR000330 SNF2-related
IPR001650 Helicase, C-terminal
IPR006935 Helicase/UvrB domain
IPR011545 DEAD/DEAH box helicase domain
IPR013967 Rad54, N-terminal
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR021006 Histone deacetylase complex, subunit 2/3
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00176
PF00271
PF04851
PF00270
PF08658
PF11496

PRINTS

PIRSF

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q92698