InnateDB Protein
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IDBP-98131.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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VIP
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Protein Name
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vasoactive intestinal peptide
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Synonyms
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PHM27;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000356213
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InnateDB Gene
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IDBG-98129 (VIP)
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Protein Structure
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Function |
VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder. {ECO:0000269PubMed:15013843}.PHM and PHV also cause vasodilation. PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin. {ECO:0000269PubMed:15013843}.
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Subcellular Localization |
Secreted.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0001938
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positive regulation of endothelial cell proliferation
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GO:0007186
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G-protein coupled receptor signaling pathway
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GO:0007589
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body fluid secretion
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GO:0007611
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learning or memory
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GO:0008284
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positive regulation of cell proliferation
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GO:0009966
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regulation of signal transduction
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GO:0010579
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positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
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GO:0032880
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regulation of protein localization
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GO:0043066
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negative regulation of apoptotic process
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GO:0043267
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negative regulation of potassium ion transport
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GO:0045732
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positive regulation of protein catabolic process
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GO:0045909
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positive regulation of vasodilation
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GO:0048662
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negative regulation of smooth muscle cell proliferation
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GO:0051930
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regulation of sensory perception of pain
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GO:0060406
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positive regulation of penile erection
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Cellular Component |
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PDB ID |
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InterPro |
IPR000532
Glucagon/GIP/secretin/VIP
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PFAM |
PF00123
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PRINTS |
PR00275
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PIRSF |
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SMART |
SM00070
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TIGRFAMs |
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Modification |
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SwissProt |
P01282
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PhosphoSite |
PhosphoSite-P01282
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
7432
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UniGene |
Hs.742000
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RefSeq |
NP_003372
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HUGO |
HGNC:12693
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OMIM |
192320
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CCDS |
CCDS5240
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HPRD |
15950
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IMGT |
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EMBL |
AL133356
BC009794
L00154
L00155
L00156
L00157
M11549
M11550
M11551
M11552
M11553
M14619
M14620
M14621
M14622
M14623
M31645
M32162
M33027
M36606
M36607
M36608
M36609
M36610
M36634
M54930
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GenPept |
AAA61284
AAA61285
AAA61286
AAA61287
AAA61288
AAA61289
AAA63268
AAA69515
AAH09794
CAI21764
CAI21765
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