InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EIF3J

Summary

InnateDB Protein

IDBP-9815.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EIF3J

Protein Name

eukaryotic translation initiation factor 3, subunit J

Synonyms

eIF3-alpha; eIF3-p35; EIF3S1;

Species

Homo sapiens

Ensembl Protein

ENSP00000261868

InnateDB Gene

IDBG-9813 (EIF3J)

Protein Structure

UniProt Annotation

Function

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA.

Subcellular Localization

Cytoplasm {ECO:0000255HAMAP-Rule:MF_03009}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.

Experimentally validated
Total	35 [view]
Protein-Protein	35 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003743	translation initiation factor activity
GO:0005515	protein binding

Biological Process

GO:0001731	formation of translation preinitiation complex
GO:0006412	translation
GO:0006413	translational initiation
GO:0006446	regulation of translational initiation
GO:0010467	gene expression
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005852	eukaryotic translation initiation factor 3 complex
GO:0016282	eukaryotic 43S preinitiation complex
GO:0033290	eukaryotic 48S preinitiation complex