InnateDB Protein
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IDBP-98184.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RGS17
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Protein Name
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regulator of G-protein signaling 17
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000206262
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InnateDB Gene
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IDBG-98182 (RGS17)
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Protein Structure
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Function |
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G- protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity). {ECO:0000250}.
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Subcellular Localization |
Membrane; Lipid-anchor. Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm/cell membrane and the nucleus. Anchored to the membrane through palmitoylation (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Predominantly expressed in the cerebellum. Also expressed in the cortex and medulla. Weakly expressed in a number of peripheral tissues notably spleen, lung and leukocytes. {ECO:0000269PubMed:15096504}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005096
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GTPase activator activity
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Biological Process |
GO:0008277
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regulation of G-protein coupled receptor protein signaling pathway
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GO:0038032
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termination of G-protein coupled receptor signaling pathway
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GO:0043547
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positive regulation of GTPase activity
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Cellular Component |
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PDB ID |
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InterPro |
IPR000342
Regulator of G protein signalling domain
IPR016137
Regulator of G protein signalling superfamily
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PFAM |
PF00615
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PRINTS |
PR01301
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PIRSF |
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SMART |
SM00315
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UGC6
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PhosphoSite |
PhosphoSite-Q9UGC6
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
26575
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UniGene |
Hs.606155
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RefSeq |
NP_036551
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HUGO |
HGNC:14088
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OMIM |
607191
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CCDS |
CCDS5244
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HPRD |
06223
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IMGT |
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EMBL |
AF202257
AF493938
AL080276
BC013117
BT006997
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GenPept |
AAF08978
AAH13117
AAM12652
AAP35643
CAI18900
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