InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CYP4Z1

Summary

InnateDB Protein

IDBP-98236.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP4Z1

Protein Name

cytochrome P450, family 4, subfamily Z, polypeptide 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000334246

InnateDB Gene

IDBG-98234 (CYP4Z1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:15059886}; Single-pass type II membrane protein {ECO:0000269PubMed:15059886}. Microsome membrane {ECO:0000269PubMed:15059886}; Single-pass type II membrane protein {ECO:0000269PubMed:15059886}.

Disease Associations

Tissue Specificity

Preferentially detected in breast carcinoma tissue and mammary gland, whereas only marginal expression is found in all other tested tissues. {ECO:0000269PubMed:15059886}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding
GO:0070330	aromatase activity

Biological Process

GO:0055114

oxidation-reduction process

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR002402 Cytochrome P450, E-class, group II
IPR002403 Cytochrome P450, E-class, group IV

PFAM

PF00067

PRINTS

PR00385
PR00463
PR00464
PR00465

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q86W10