InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CYP4A22

Summary

InnateDB Protein

IDBP-98256.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP4A22

Protein Name

cytochrome P450, family 4, subfamily A, polypeptide 22

Synonyms

CP4Y; CYP4A2; CYP4AII;

Species

Homo sapiens

Ensembl Protein

ENSP00000294337

InnateDB Gene

IDBG-98250 (CYP4A22)

Protein Structure

UniProt Annotation

Function

Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate and palmitate. Shows no activity towards arachidonic acid and prostaglandin A1. Lacks functional activity in the kidney and does not contribute to renal 20-hydroxyeicosatetraenoic acid (20-HETE) biosynthesis. {ECO:0000269PubMed:10860550, ECO:0000269PubMed:15611369}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0018685	alkane 1-monooxygenase activity
GO:0020037	heme binding
GO:0052869	arachidonic acid omega-hydroxylase activity

Biological Process

GO:0055114

oxidation-reduction process

Cellular Component

GO:0005789

endoplasmic reticulum membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR002402 Cytochrome P450, E-class, group II
IPR002403 Cytochrome P450, E-class, group IV

PFAM

PF00067

PRINTS

PR00385
PR00463
PR00464
PR00465

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5TCH4