InnateDB Protein
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IDBP-98264.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TAL1
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Protein Name
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T-cell acute lymphocytic leukemia 1
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Synonyms
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bHLHa17; SCL; tal-1; TCL5;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000360951
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InnateDB Gene
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IDBG-98262 (TAL1)
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Protein Structure
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Function |
Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00981}.
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Disease Associations |
Note=A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes.
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Tissue Specificity |
Leukemic stem cell.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 76 experimentally validated interaction(s) in this database.
They are also associated with 292 interaction(s) predicted by orthology.
Experimentally validated |
Total |
79
[view]
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Protein-Protein |
75
[view]
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Protein-DNA |
4
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
292 [view]
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Molecular Function |
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Biological Process |
GO:0006357
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regulation of transcription from RNA polymerase II promoter
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GO:0030097
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hemopoiesis
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GO:0030218
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erythrocyte differentiation
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GO:0030219
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megakaryocyte differentiation
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GO:0030221
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basophil differentiation
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GO:0031334
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positive regulation of protein complex assembly
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GO:0035162
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embryonic hemopoiesis
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GO:0045165
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cell fate commitment
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GO:0045648
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positive regulation of erythrocyte differentiation
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GO:0045799
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positive regulation of chromatin assembly or disassembly
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GO:0045893
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positive regulation of transcription, DNA-templated
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GO:0045931
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positive regulation of mitotic cell cycle
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0051781
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positive regulation of cell division
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Cellular Component |
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PDB ID |
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InterPro |
IPR011598
Myc-type, basic helix-loop-helix (bHLH) domain
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PFAM |
PF00010
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PRINTS |
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PIRSF |
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SMART |
SM00353
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TIGRFAMs |
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Modification |
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SwissProt |
P17542
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PhosphoSite |
PhosphoSite-P17542
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TrEMBL |
Q9UE36
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UniProt Splice Variant |
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Entrez Gene |
6886
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UniGene |
Hs.737706
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RefSeq |
NP_001277335
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HUGO |
HGNC:11556
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OMIM |
187040
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CCDS |
CCDS547
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HPRD |
01753
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IMGT |
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EMBL |
AL135960
CH471059
M29038
M61103
M61104
M61105
M61108
M63572
M63576
M63584
M63589
X51990
X58621
X58622
X58623
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GenPept |
AAA36598
AAA36599
AAA36600
CAA36246
CAA41476
CAA41477
CAA41478
CAB72103
EAX06875
EAX06876
EAX06877
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