InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TAL1

Summary

InnateDB Protein

IDBP-98268.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAL1

Protein Name

T-cell acute lymphocytic leukemia 1

Synonyms

bHLHa17; SCL; tal-1; TCL5;

Species

Homo sapiens

Ensembl Protein

ENSP00000294339

InnateDB Gene

IDBG-98262 (TAL1)

Protein Structure

UniProt Annotation

Function

Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00981}.

Disease Associations

Note=A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes.

Tissue Specificity

Leukemic stem cell.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 76 experimentally validated interaction(s) in this database.
They are also associated with 292 interaction(s) predicted by orthology.

Experimentally validated
Total	79 [view]
Protein-Protein	75 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	292 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001085	RNA polymerase II transcription factor binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0042826	histone deacetylase binding
GO:0044212	transcription regulatory region DNA binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity
GO:0070888	E-box binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001525	angiogenesis
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007626	locomotory behavior
GO:0021527	spinal cord association neuron differentiation
GO:0030097	hemopoiesis
GO:0030099	myeloid cell differentiation
GO:0030182	neuron differentiation
GO:0030218	erythrocyte differentiation
GO:0030219	megakaryocyte differentiation
GO:0030220	platelet formation
GO:0030221	basophil differentiation
GO:0031334	positive regulation of protein complex assembly
GO:0035162	embryonic hemopoiesis
GO:0035855	megakaryocyte development
GO:0042127	regulation of cell proliferation
GO:0043249	erythrocyte maturation
GO:0045165	cell fate commitment
GO:0045637	regulation of myeloid cell differentiation
GO:0045648	positive regulation of erythrocyte differentiation
GO:0045799	positive regulation of chromatin assembly or disassembly
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045931	positive regulation of mitotic cell cycle
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048699	generation of neurons
GO:0051781	positive regulation of cell division
GO:0060018	astrocyte fate commitment
GO:0060216	definitive hemopoiesis
GO:0060217	hemangioblast cell differentiation
GO:0060218	hematopoietic stem cell differentiation
GO:0060375	regulation of mast cell differentiation
GO:2000036	regulation of stem cell maintenance

Cellular Component

GO:0000118	histone deacetylase complex
GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0033193	Lsd1/2 complex
GO:0043234	protein complex