InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NOX3

Summary

InnateDB Protein

IDBP-98307.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NOX3

Protein Name

NADPH oxidase 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000159060

InnateDB Gene

IDBG-98305 (NOX3)

Protein Structure

UniProt Annotation

Function

NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. {ECO:0000269PubMed:15824103}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016175	superoxide-generating NADPH oxidase activity
GO:0016491	oxidoreductase activity

Biological Process

GO:0001659	temperature homeostasis
GO:0009590	detection of gravity
GO:0009629	response to gravity
GO:0042554	superoxide anion generation
GO:0048840	otolith development
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0043020	NADPH oxidase complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000778 Cytochrome b245, heavy chain
IPR008333 Oxidoreductase, FAD-binding domain
IPR013112 FAD-binding 8
IPR013121 Ferric reductase, NAD binding
IPR013130 Ferric reductase transmembrane component-like domain
IPR017938 Riboflavin synthase-like beta-barrel

PFAM

PF00970
PF08022
PF08030
PF01794

PRINTS

PR00466

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9HBY0