Version 5.4
Homo sapiens Protein: AGBL4
Summary
InnateDB Protein IDBP-98347.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AGBL4
Protein Name ATP/GTP binding protein-like 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000360905
InnateDB Gene IDBG-98345 (AGBL4)
Protein Structure
UniProt Annotation
Function Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5 (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004181 metallocarboxypeptidase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0015631 tubulin binding
Biological Process
GO:0006508 proteolysis
GO:0035609 C-terminal protein deglutamylation
GO:0035610 protein side chain deglutamylation
Cellular Component
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR000834 Peptidase M14, carboxypeptidase A
PFAM PF00246
PRINTS PR00765
PIRSF
SMART SM00631
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5VU57
PhosphoSite PhosphoSite-Q5VU57
TrEMBL B4DGK1
UniProt Splice Variant
Entrez Gene 84871
UniGene Hs.679809
RefSeq NP_116174
HUGO HGNC:25892
OMIM
CCDS CCDS44137
HPRD 07487
IMGT
EMBL AC092264 AC097062 AC099788 AC105766 AK094826 AK294394 AK294633 AL031294 AL355809 AL356789 AL356916 AL390023 AL391844 AL445527 AL590432 AL591602 AL645507 AL645730
GenPept BAG52938 BAG57648 BAG57812 CAH70510 CAI13521 CAI14372 CAI17069 CAI19137 CAI22167 CAI23365

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca