InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TULP4

Summary

InnateDB Protein

IDBP-98433.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TULP4

Protein Name

tubby like protein 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000356064

InnateDB Gene

IDBG-98431 (TULP4)

Protein Structure

UniProt Annotation

Function

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000250}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Expressed mainly in the brain, skeletal muscle, testis and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0007584	response to nutrient
GO:0016567	protein ubiquitination
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000007 Tubby, C-terminal
IPR001496 SOCS protein, C-terminal
IPR001680 WD40 repeat
IPR008983 Tumour necrosis factor-like domain
IPR017986 WD40-repeat-containing domain
IPR025659 Tubby C-terminal-like domain

PFAM

PF01167
PF07525
PF00400

PRINTS

PR01573

PIRSF

SMART

SM00253
SM00969
SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt