Version 5.4
Homo sapiens Protein: TMEM181
Summary
InnateDB Protein IDBP-98453.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMEM181
Protein Name transmembrane protein 181
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000356057
InnateDB Gene IDBG-98447 (TMEM181)
Protein Structure
UniProt Annotation
Function Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria. Expression level of TMEM181 is rate-limiting for intoxication. {ECO:0000269PubMed:19965467}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0015643 toxic substance binding
Biological Process
GO:0009405 pathogenesis
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9P2C4
PhosphoSite PhosphoSite-Q9P2C4
TrEMBL
UniProt Splice Variant
Entrez Gene 57583
UniGene Hs.99145
RefSeq NP_065874
HUGO HGNC:20958
OMIM 613209
CCDS CCDS43520
HPRD
IMGT
EMBL AB037844 AL591025
GenPept BAA92661 CAH70179

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca