InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EZR

Summary

InnateDB Protein

IDBP-98479.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EZR

Protein Name

ezrin

Synonyms

CVIL; CVL; HEL-S-105; VIL2;

Species

Homo sapiens

Ensembl Protein

ENSP00000338934

InnateDB Gene

IDBG-98477 (EZR)

Protein Structure

UniProt Annotation

Function

Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. {ECO:0000269PubMed:17881735, ECO:0000269PubMed:18270268, ECO:0000269PubMed:19111582}.

Subcellular Localization

Apical cell membrane {ECO:0000269PubMed:18046454}; Peripheral membrane protein {ECO:0000269PubMed:18046454}; Cytoplasmic side {ECO:0000269PubMed:18046454}. Cell projection {ECO:0000269PubMed:18046454}. Cell projection, microvillus membrane {ECO:0000269PubMed:18046454}; Peripheral membrane protein {ECO:0000269PubMed:18046454}; Cytoplasmic side {ECO:0000269PubMed:18046454}. Cell projection, ruffle membrane {ECO:0000269PubMed:18046454}; Peripheral membrane protein {ECO:0000269PubMed:18046454}; Cytoplasmic side {ECO:0000269PubMed:18046454}. Cytoplasm, cell cortex {ECO:0000269PubMed:18046454}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:18046454}. Note=Localization to the apical membrane of parietal cells depends on the interaction with MPP5. Localizes to cell extensions and peripheral processes of astrocytes (By similarity). Microvillar peripheral membrane protein (cytoplasmic side). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. Weakly expressed in brain stem and diencephalon. Stronger expression was detected in gray matter of frontal lobe compared to white matter (at protein level). Component of the microvilli of intestinal epithelial cells. Preferentially expressed in astrocytes of hippocampus, frontal cortex, thalamus, parahippocampal cortex, amygdala, insula, and corpus callosum. Not detected in neurons in most tissues studied. {ECO:0000269PubMed:15797715}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 138 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	138 [view]
Protein-Protein	135 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0044822	poly(A) RNA binding
GO:0050839	cell adhesion molecule binding
GO:0051015	actin filament binding

Biological Process

GO:0007016	cytoskeletal anchoring at plasma membrane
GO:0007159	leukocyte cell-cell adhesion
GO:0007411	axon guidance
GO:0008360	regulation of cell shape
GO:0010628	positive regulation of gene expression
GO:0022614	membrane to membrane docking
GO:0051017	actin filament bundle assembly
GO:0061028	establishment of endothelial barrier

Cellular Component

GO:0001726	ruffle
GO:0005615	extracellular space
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005884	actin filament
GO:0005886	plasma membrane
GO:0005902	microvillus
GO:0005925	focal adhesion
GO:0015629	actin cytoskeleton
GO:0016020	membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0019898	extrinsic component of membrane
GO:0030175	filopodium
GO:0030863	cortical cytoskeleton
GO:0031528	microvillus membrane
GO:0032587	ruffle membrane
GO:0045177	apical part of cell
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000299 FERM domain
IPR000798 Ezrin/radixin/moesin like
IPR008954 Moesin tail domain
IPR011174 Ezrin/radixin/moesin
IPR011259 Ezrin/radixin/moesin, C-terminal
IPR018979 FERM, N-terminal
IPR018980 FERM, C-terminal PH-like domain
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR019750 Band 4.1 family
IPR029071 Ubiquitin-related domain

PFAM

PF00769
PF09379
PF09380
PF00373

PRINTS

PR00661
PR00935

PIRSF

PIRSF002305

SMART

SM00295

TIGRFAMs

Post-translational Modifications

Modification

Cross-References