InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TCP1

Summary

InnateDB Protein

IDBP-98572.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TCP1

Protein Name

t-complex 1

Synonyms

CCT-alpha; CCT1; CCTa; D6S230E; TCP-1-alpha;

Species

Homo sapiens

Ensembl Protein

ENSP00000317334

InnateDB Gene

IDBG-98570 (TCP1)

Protein Structure

UniProt Annotation

Function

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin. {ECO:0000269PubMed:20080638}.

Subcellular Localization

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 143 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	143 [view]
Protein-Protein	139 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0044822	poly(A) RNA binding
GO:0051082	unfolded protein binding

Biological Process

GO:0006457	protein folding
GO:0007021	tubulin complex assembly
GO:0007339	binding of sperm to zona pellucida
GO:0044267	cellular protein metabolic process
GO:0051084	'de novo' posttranslational protein folding

Cellular Component

GO:0000242	pericentriolar material
GO:0000792	heterochromatin
GO:0001669	acrosomal vesicle
GO:0002199	zona pellucida receptor complex
GO:0005720	nuclear heterochromatin
GO:0005794	Golgi apparatus
GO:0005813	centrosome
GO:0005815	microtubule organizing center
GO:0005829	cytosol
GO:0005832	chaperonin-containing T-complex
GO:0005874	microtubule
GO:0044297	cell body
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001844 Chaperonin Cpn60
IPR002423 Chaperonin Cpn60/TCP-1
IPR017998 Chaperone tailless complex polypeptide 1 (TCP-1)
IPR027409 GroEL-like apical domain

PFAM

PF00118

PRINTS

PR00298
PR00304

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P17987