Version 5.4
Homo sapiens Protein: CC2D1B
Summary
InnateDB Protein IDBP-98619.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CC2D1B
Protein Name coiled-coil and C2 domain containing 1B
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000360642
InnateDB Gene IDBG-98617 (CC2D1B)
Protein Structure
UniProt Annotation
Function Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. {ECO:0000269PubMed:19423080}.
Subcellular Localization Nucleus {ECO:0000269PubMed:19423080}.
Disease Associations
Tissue Specificity Widely distributed in brain and peripheral tissues. {ECO:0000269PubMed:19423080}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR000008 C2 domain
IPR006608 Domain of unknown function DM14
PFAM PF00168
PRINTS PR00360
PIRSF
SMART SM00239
SM00685
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5T0F9
PhosphoSite PhosphoSite-Q5T0F9
TrEMBL
UniProt Splice Variant
Entrez Gene 200014
UniGene Hs.734973
RefSeq NP_115825
HUGO HGNC:29386
OMIM
CCDS CCDS30714
HPRD 12393
IMGT
EMBL AB058739 AK130874 AL513218 BC007912 BC016880 BC039308
GenPept AAH07912 AAH16880 AAH39308 BAB47465 BAC85450 CAI12282 CAI12283 CAI12284

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca