Version 5.4
Homo sapiens Protein: GPR31
Summary
InnateDB Protein IDBP-99059.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPR31
Protein Name G protein-coupled receptor 31
Synonyms 12-HETER; HETER; HETER1;
Species Homo sapiens
Ensembl Protein ENSP00000355799
InnateDB Gene IDBG-99057 (GPR31)
Protein Structure
UniProt Annotation
Function High-affinity receptor for 12-(S)-hydroxy-5,8,10,14- eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secreted by platelets and tumor cells, and known to induce endothelial cells retraction allowing invasive cell access to the subendothelial matrix, which is a critical step for extravasation or metastasis. Ligand-binding lead to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B. {ECO:0000269PubMed:21712392}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:21712392}; Multi-pass membrane protein {ECO:0000269PubMed:21712392}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
PFAM PF00001
PRINTS PR00237
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O00270
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 2853
UniGene Hs.248124
RefSeq NP_005290
HUGO HGNC:4486
OMIM 602043
CCDS CCDS5299
HPRD 03622
IMGT
EMBL AL121935 BC095537 CH471051 EU432117 U65402
GenPept AAC51375 AAH95537 ABY87916 CAB99329 EAW47505

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca