InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: USP24

Summary

InnateDB Protein

IDBP-99093.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

USP24

Protein Name

ubiquitin specific peptidase 24

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000294383

InnateDB Gene

IDBG-99091 (USP24)

Protein Structure

UniProt Annotation

Function

Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Deubiquitinates DDB2, preventing its proteasomal degradation. {ECO:0000269PubMed:23159851}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0008234	cysteine-type peptidase activity
GO:0036459	ubiquitinyl hydrolase activity

Biological Process

GO:0006511

ubiquitin-dependent protein catabolic process

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR009060 UBA-like
IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
IPR016024 Armadillo-type fold
IPR028889 Ubiquitin carboxyl-terminal hydrolase-like domain
IPR029071 Ubiquitin-related domain

PFAM

PF00443

PRINTS

PIRSF

SMART

SM00165

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9UPU5