InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DOK2

Summary

InnateDB Protein

IDBP-9915.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DOK2

Protein Name

docking protein 2, 56kDa

Synonyms

p56DOK; p56dok-2;

Species

Homo sapiens

Ensembl Protein

ENSP00000276420

InnateDB Gene

IDBG-9913 (DOK2)

Protein Structure

UniProt Annotation

Function

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Highly expressed in peripheral blood leukocytes, lymph nodes and spleen. Lower expression in thymus, bone marrow and fetal liver. {ECO:0000269PubMed:9478921}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005057	receptor signaling protein activity
GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005158	insulin receptor binding

Biological Process

GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007265	Ras protein signal transduction
GO:0007596	blood coagulation
GO:0050900	leukocyte migration