InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: OMA1

Summary

InnateDB Protein

IDBP-99209.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OMA1

Protein Name

OMA1 homolog, zinc metallopeptidase (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000360270

InnateDB Gene

IDBG-99205 (OMA1)

Protein Structure

UniProt Annotation

Function

Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions. {ECO:0000269PubMed:20038677}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000305PubMed:20038677}; Multi-pass membrane protein {ECO:0000305PubMed:20038677}.

Disease Associations

Tissue Specificity

Widely expressed, with strong expression in the heart, skeletal muscle, kidney and liver. {ECO:0000269PubMed:12886954}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0046872	metal ion binding

Biological Process

GO:0002024	diet induced thermogenesis
GO:0006006	glucose metabolic process
GO:0006508	proteolysis
GO:0006515	misfolded or incompletely synthesized protein catabolic process
GO:0006629	lipid metabolic process
GO:0006950	response to stress
GO:0007005	mitochondrion organization
GO:0010637	negative regulation of mitochondrial fusion
GO:0034982	mitochondrial protein processing
GO:0042407	cristae formation
GO:0097009	energy homeostasis

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031966	mitochondrial membrane