InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: INADL

Summary

InnateDB Protein

IDBP-99338.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

INADL

Protein Name

InaD-like (Drosophila)

Synonyms

Cipp; hINADL; InaD-like; PATJ;

Species

Homo sapiens

Ensembl Protein

ENSP00000360200

InnateDB Gene

IDBG-99328 (INADL)

Protein Structure

UniProt Annotation

Function

Scaffolding protein that may bring different proteins into adjacent positions at the cell membrane. May regulate protein targeting, cell polarity and integrity of tight junctions. May regulate the surface expression and/or function of ASIC3 in sensory neurons. {ECO:0000269PubMed:11927608}.

Subcellular Localization

Membrane. Cell junction, tight junction. Apical cell membrane. Cytoplasm, perinuclear region. Note=Localized in the paranodal region of myelinating Schwann cells (By similarity). Membrane-associated. Localizes to tight junctions in epithelial cells. Also found at the apical plasma membrane. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in bladder, testis, ovary, small intestine, colon, heart, skeletal muscle, pancreas and cerebellum in the brain. {ECO:0000269PubMed:11964389, ECO:0000269PubMed:9280290}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	49 [view]
Protein-Protein	47 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0034329	cell junction assembly
GO:0035556	intracellular signal transduction
GO:0045216	cell-cell junction organization
GO:0070830	tight junction assembly

Cellular Component

GO:0005886	plasma membrane
GO:0005923	tight junction
GO:0016324	apical plasma membrane
GO:0043234	protein complex
GO:0045177	apical part of cell
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome